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1 article(s) from Onishi, Yasuhiko

Anticancer efficacy of a supramolecular complex of a 2-diethylaminoethyl–dextran–MMA graft copolymer and paclitaxel used as an artificial enzyme

Yasuhiko Onishi,
Yuki Eshita,
Rui-Cheng Ji,
Masayasu Onishi,
Takashi Kobayashi,
Masaaki Mizuno,
Jun Yoshida and
Naoji Kubota

Beilstein J. Nanotechnol. 2014, 5, 2293–2307, doi:10.3762/bjnano.5.238

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Figure 1: Non-viral vectoring of DEAE–dextran and DEAE–dextran–MMA graft copolymer (DDMC). (a) Transfection o...

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Figure 2: Differential scanning calorimetry (DSC) with DDMC–paclitaxel complex and paclitaxel: (1) DDMC, (2) ...

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Figure 3: IR absorption spectra of the DDMC–paclitaxel complex and paclitaxel. (a) Mid-infrared region (4.000...

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Figure 4: Characteristics of the DDMC–paclitaxel complex. (a) Particle size distribution and ζ-potential of t...

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Figure 5: Anticancer efficacy of a supramolecular complex against PTX-resistant melanoma B16F10 cells. (a) Su...

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Figure 6: Potential energy curve of paclitaxel (large) and DDMC/PTX complex (small) in the tumor inhibition r...

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Figure 7: In vivo analysis of the anticancer activity and survival rates of the DDMC/PTX complex in B16F10 me...

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Figure 8: Two mice of both PTX (left) and DDMC/PTX4 (right) groups after 208 hours from I.P. In the mice of D...

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Figure 9: α,β-tubulin dimer orientates with the active site (i.e., paclitaxel) of the DDMC/PTC complex. The D...

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Figure 10: Schematic representation of α,β-tubulin dimer polymerization showing the allosteric relationship be...

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Review

Published 01 Dec 2014

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